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米非司酮造成再次妊娠流产和胎盘并发症

Mifepristone-induced abortion and placental complications in subsequent pregnancy
Zhu Q.-X., Gao E.-S., Chen A.-M., Luo L., Cheng Y.-M., Yuan W.   |   2009/5/29 18:39:42 
Human Reproduction, 2009   |   Volume 24, Issue 2  |   打印| 推荐给好友
上一篇: 溶质转运家族30 （锌转运体）成员8 （ SLC30A8 ）的遗传多态性与多囊卵巢综合征不相关
下一篇: 一例携带t(1:21)相互易位的男性无精症患者的异常突触和重组
BACKGROUND: The aim of the study was to explore the effect of first-trimester mifepristone-induced abortion (MA) on placental complications in subsequent pregnancy. METHODS: Two cohorts of nulliparous pregnant women were recruited in China during early pregnancy, one with a history of one MA and the other with no abortion (NA). Women were followed up until delivery. RESULTS: The incidence proportions of abruptio placenta, placenta previa, placenta accreta and retained placenta in the MA group (4673) and NA group (4690) were, respectively, 0.5 and 0.3, 0.8 and 0.9, 0.5 and 0.5, and 0.7 and 0.8% (all differences non-significant). After adjustment for center, age, education, occupation, residence, income, BMI and type of delivery, the incidence rates of placenta previa, accreta and retained placenta in the MA and NA groups showed no significant differences. The risk of abruptio placenta in women with a MA was nearly double that of women with no abortion, although this apparent increased risk was not statistically significant. Furthermore, this increased risk of abruptio placenta was found only in those with a gestational age >6 weeks at abortion (aOR: 2.46; 95% CI: 1.00-6.04), a curettage after abortion (aOR: 3.00; 95% CI: 1.25-7.20) or a longer inter-pregnancy interval (P-value for trend: 0.022). CONCLUSIONS: Mifepristone-induced abortion itself is not associated with placental complications in subsequent pregnancy, but other factors related to medical abortion - such as a gestational age >6 weeks at abortion, a curettage after abortion, and a longer interpregnancy interval - may increase the risk of abruptio placenta. © The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Correspondence Address: Yuan, W.2140 Xietu Road, Shanghai 200032, China; email: yuanwei@sippr.stc.sh.cn 
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慢性心衰诊治：规范中求突破
黄峻
2012-2-1
南京医科大学第一附属医院
房颤治疗：手段渐趋丰富 新型治疗药物不断涌现 非药物治疗备受关注
马长生
2012-2-1
首都医科大学附属北京安贞医院
注重老年人群特征 优化管理

刘梅林
2012-2-1
北京大学第一医院老年内科

 
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