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子宫内膜异位症妇女原位子宫内膜黏着斑激酶表达的改变

Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis
Mu L., Zheng W., Wang L., Chen X.-J., Zhang X., Yang J.-H.   |   2009/5/29 18:39:43 
Fertility and Sterility, 2008   |   Volume 89, Issue 3  |   打印| 推荐给好友
上一篇: 体外成熟期间暴露于人类绒毛膜促性腺激素不提高多囊卵巢综合征患者未成熟卵母细胞的成熟率和发育潜能
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Objective: To investigate whether focal adhesion kinase (FAK) expression is altered in eutopic endometrium of women with endometriosis. Design: Experimental study using human endometrial tissue. Setting: Academic research center. Patient(s): Women with or without endometriosis who were undergoing surgery for benign indications. Intervention(s): Endometrial biopsy. Main Outcome Measure(s): Expression of FAK was assessed by immunohistochemistry, Western blotting analysis, and reverse-transcription polymerase chain reaction. Result(s): At secretory phase, the average level of endometrial FAK expression of women with endometriosis was significantly higher than that of controls, but no significant difference was found between the two groups at proliferative phase. There was a positive correlation between FAK expression in secretory endometrial tissues and disease stage and pelvic pain in women with endometriosis. Furthermore, the endometrial FAK protein expression varied with the serum E2 at proliferative phase and with the ratio of E2 to P at secretory phase. Conclusion(s): The study showed a significant increase of FAK expression in the secretory endometrial tissues of women with endometriosis, a relationship between FAK expression and disease stage, pelvic pain, and serum steroid hormones. Those results suggest that FAK may play a role in the pathogenesis of endometriosis and be regulated by steroid hormones. © 2008 American Society for Reproductive Medicine.
Correspondence Address: Zheng, W.; Department of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang, China; email: dwzheng00@yahoo.com 
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