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肝细胞肝癌X连锁细胞凋亡抑制物蛋白的表达促进肿瘤转移和复发

Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence
Shi Y.-H., Ding W.-X., Zhou J., He J.-Y., Xu Y., Gambotto A.A., Rabinowich H., Fan J., Yin X.-M.   |   2009/5/29 18:40:09 
Hepatology, 2008   |   Volume 48, Issue 2  |   打印| 推荐给好友
上一篇: 蜂毒溶血肽通过抑制Rac 1-依赖通路预防肝癌细胞转移
下一篇: 肝细胞肝癌1q21常规扩增区域分离并鉴定的新型癌基因在肝癌1中过度表达
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Despite significantly improved diagnosis and treatment in recent years, the long-term therapeutic effect is compromised by the frequent recurrence and metastasis, of which the molecular mechanisms are not fiAly understood. Our initial studies in established HCC cell lines with different metastatic capabilities indicated a correlation of metastasis with the resistance to apoptosis and therefore the ability to survive in stressed conditions. Subsequent investigation revealed that increased expression of X-linked inhibitor-of-apoptosis protein (XIAP) was correlated with the resistance to apoptosis and enhanced invasiveness in vitro, which could contribute to increased metastatic foci in vivo. Furthermore, we found that nearly 90% of clinical samples from advanced HCC patients expressed high levels of XIAP. Patients with XIAP-positive tumors had a significantly increased risk of relapse, which resulted from metastasis after total liver resection and orthotopic liver transplantation. Indeed, XIAP expression could be an independent prognostic factor for predicting disease-free survival rate and overall survival rate of these patients. XIAP expression was also highly correlated with advanced cases that exceeded the Milan criteria and could be a prognostic factor for disease-free survival in these patients as well. Conclusion: Our studies have shown an important molecule in controlling HCC metastasis, defined a biomarker that can be used to predict HCC recurrence and patient survival after treatment, and suggest that XIAP can be a molecular target subject to intervention to reduce metastasis and recurrence. Copyright © 2008 by the American Association for the Study of Liver Diseases.
Correspondence Address: Yin, X.-M.; Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, United States; email: xmyin@pitt.edu 
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慢性心衰诊治：规范中求突破
黄峻
2012-2-1
南京医科大学第一附属医院
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首都医科大学附属北京安贞医院
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