Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29×106/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-γ test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-γ test does not exclude TB disease in immunosuppressed patients.
 

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