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Framingham研究最新数据显示:糖尿病患者的心血管风险因素控制仍不理想

Framingham: Cardiovascular Risk Factors Remain Suboptimal in Diabetics

By Bruce Jancin 2010-02-05 【发表评论】
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Elsevier Global Medical News
Conferences in Depth 爱思唯尔全球医学资讯
会议深度报道

SNOWMASS, COLORADO(EGMN) Optimal control of cardiovascular risk factors in diabetic patients in the community setting remains an elusive goal, according to the most recent data from the Framingham Heart Study.

Individuals with diabetes have a two- to threefold greater rate of cardiovascular disease than do those without the disease. Aggressive control of their cardiovascular risk factors is essential to overcome this markedly increased risk. But the Framingham experience demonstrates that it is not happening, Dr. Patrick O’Gara observed at a conference sponsored by the American College of Cardiology.

A bright spot is the low prevalence of cigarette smoking, down to just under 13% during 2000-2005 in 60-year-olds with diabetes in Framingham. That’s even lower than the 17% smoking rate among comparable-age individuals without diabetes.

This rejection of smoking by the Framingham diabetic population over the last 3 decades has been particularly impressive: The prevalence among 60-year-olds with diabetes has steadily fallen from nearly 42% during 1970-1979, to 27.5% in 1980-1989, 18% in 1990-1999, and down to 12.8% in the first half of the last decade, noted Dr. O’Gara of Brigham and Women’s Hospital, Boston.

Hypertension is another story altogether. The prevalence of hypertension among 60-year-olds with diabetes in 2000-2005 was 87%, more than twice that of nondiabetic individuals. Moreover, the prevalence of hypertension among the diabetic population was essentially unchanged since 1970.

The rate of controlled hypertension was less than 27% in 60-year-old diabetic men and women in Framingham during 2000-2005, compared with 45.5% in those without diabetes (Circulation 2009;120:212-20).

Only 40% of diabetic individuals with high LDL cholesterol had it controlled to guideline target levels in 2000-2005. That’s better than the 32% rate among those without diabetes, and a huge improvement over the 13.5% rate in diabetic 60-year-olds during 1990-1999, but a far cry from what is required to erase the high excess cardiovascular risk among the diabetic population, Dr. O’Gara noted.

The prevalence of obesity among diabetic 60-year-olds in 2000-2005 was more than 67%, up sharply from 46% during the prior decade. The rise in obesity among nondiabetic 60-year-olds was considerably less dramatic, from a 26% prevalence in 1990-1999 to 33% in the most recent data.

“I think we all understand the magnitude of the problem and that some of the solutions to this problem are larger than what we can do on an individual basis, but I encourage us all to keep our eyes on the prize,” Dr. O’Gara concluded.

The Framingham Heart Study is funded by the U.S. National Heart, Lung, and Blood Institute. Dr. O’Gara reported having no relevant financial interests.

Copyright (c) 2009 Elsevier Global Medical News. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

科罗拉多州,斯诺马斯(EGMN)——根据Framingham心脏研究的最新资料,在社区机构中对糖尿病患者的心血管危险因素给予最佳控制的目标仍很难达到。

糖尿病患者的心血管疾病发生率为非糖尿病个体的2~3倍。为了控制这种显著增高的风险,必须对心血管危险因素给予积极控制。但Patrick O'Gara博士在美国心脏病学会主办的一次会议上指出,Framingham研究数据显示,实际情况并非如此。
 
该研究数据中的一个亮点是,吸烟者比例明显下降,Framingham研究数据显示,2000~2005年间,60岁的糖尿病患者中吸烟者比例已降至13%以下,较年龄相当的非糖尿病个体中的吸烟者比例(17%)更低。
 
最近30年中Framingham糖尿病人群中的戒烟成效非常引人注目:1970~1979年间,60岁糖尿病患者中吸烟者比例接近42%,之后这一比例稳步下降,在1980~1989年间降至27.5%1990~1999年间降至18%,在21世纪的前5年内降至12.8%,波士顿市Brigham妇女医院的O'Gara博士指出。
 
但高血压控制的情况却完全不同。2000~2005年间60岁糖尿病患者中高血压患病率为87%,高于非糖尿病个体的2倍。并且,自1970年后,糖尿病人群中的高血压患病率基本未发生变化。
 
Framingham研究中,2000~2005年间60岁的男、女糖尿病患者中高血压控制率不足27%,而非糖尿病人群为45.5%(Circulation 2009;120:212-20)
 
2000~2005年间,仅40%伴有LDL胆固醇增高的糖尿病个体将LDL胆固醇控制到指南规定的目标水平,高于非糖尿病个体中的控制率(32%),并且较1990~1999年间60岁糖尿病个体中的控制率(13.5%)已有大幅提高,但与在糖尿病人群中消除过高的心血管风险的要求仍相距甚远。
 
最新数据显示,2000~2005年间,60岁糖尿病人群中肥胖患病率超过67%,较之前10年间的患病率(46%)有迅猛增长。而60岁非糖尿病个体中的肥胖患病率增长较少,仅从1990~1999年间的26%增长至33%
 
我认为,我们都已经认识到问题的严重程度,并且意识到这一问题单纯从个体水平很难解决,但我仍然鼓励大家着眼于将危险因素控制在指南规定的目标范围之内, O'Gara博士总结道。
 
Framingham心脏研究由美国国立心肺血液研究院资助,O'Gara博士报告无任何相关利益冲突。
 
爱思唯尔  版权所有

Subjects:
general_primary, cardiology, endocrinology, diabetes, gerontology, general_primary
学科代码:
内科学, 心血管病学, 内分泌学与糖尿病, 老年病学, 全科医学

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病例分析 <span class="ModTitle_Intro_Right" id="EPMI_Home_MedicalCases_Intro_div" onclick="javascript:window.location='http://portal.elseviermed.cn/tabid/127/Default.aspx'" onmouseover="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.cursor='pointer';document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='underline';"  onmouseout="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='none';">[栏目介绍]</span>  病例分析 [栏目介绍]
摘自:《西氏内科学》,第23
 
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