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Volume 5, Issue 3 


中文标题:

长期他汀类药物治疗对冠心病和肝功能异常患者心血管事件的预防效应及安全性评估：一项在希腊的阿托伐他汀及...

英文标题: Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis  

作者: Vasilios G Athyros, Konstantinos Tziomalos, Thomas...

全文: 背　景　长期他汀类药物治疗可降低心血管事件的发生率，但在肝功能异常患者中其治疗的安全性与有效性尚不明确。本研究通过对希腊阿托伐他汀及冠心病评估（GREACE）研究中的人群进行回顾性分析以评估他汀类药物治疗的安全性及有效性。   方　法　GREACE是一项前瞻性意向治疗研究，通过计算机生成的随机表对希腊Hippokration大学医院1600例冠心病患者（年龄<...
 
往期免费全文
 2011
 2010
Volume 4 , Issue 12
伊伐布雷定与慢性心力衰竭结局（SHIFT）：一项安慰剂对照随机试验
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
Volume 4 , Issue 11
乳腺癌术中定向放疗与术后全乳放疗的疗效比较（TARGIT-A试验）：一项国际多中心、前瞻性、非劣效性Ⅲ期随机试验
Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial
Volume 4 , Issue 10
重组戊型肝炎病毒疫苗对健康成人的有效性和安全性：一项大型、随机、双盲、安慰剂对照III期试验
Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase
Volume 4 , Issue 9
利拉鲁肽与西他列汀治疗二甲双胍血糖控制不良2型糖尿病：一项26周、随机、平行组、开放标记试验
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial
Volume 4 , Issue 8
急性心肌梗死患者入院前行远端缺血预适应作为血管成形术的补充及其对心肌挽救的影响：一项随机研究
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
Volume 4 , Issue 7
拟行有创性治疗的急性冠状动脉综合征患者应用替卡格雷与氯吡格雷的比较（PLATO）：一项随机双盲研究
Comparison of ticagrelor with clopidogrel in patients with a planed invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study
Volume 4 , Issue 6
新辅助化疗联合与不联合曲妥珠单抗对HER-2阳性局部晚期乳腺癌的疗效（NOAH试验）：一项伴HER-2阴性平行队列的优效性随机对照试验
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
Volume 4 , Issue 5
冠心病患者心脏除颤器植入术前稳定性室性心动过速导管消融术（VTACH）：一项多中心随机对照试验
Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial
Volume 4 , Issue 4
2008年中国5岁以下儿童死亡原因
Causes of deaths in children younger than 5 years in China in 2008
Volume 4 , Issue 3
18个中低收入国家儿童残疾筛查、营养和早期教育状况分析：UNICEF第3轮多指标类集调查结果（2005—2006年）
Child disability screening, nutrition, and early learning in 18 countries with low and middle incomes: data from the third round of UNICEF’s Multiple Indicator Cluster Survey (2005–06)
Volume 4 , Issue 2
剂量密集紫杉醇联合卡铂治疗晚期卵巢癌：一项开放标记的III期随机对照试验
Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial
Volume 4 , Issue 1
未患糖尿病的高血压患者中常规与严格控制收缩压的比较（Cardio-Sis）：一项开放性随机试验
Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial
 2009
Volume 3 , Issue 12
美国1例严重毁容患者的近全颜面移植
Near-total human face transplantation for a severely disfigured patient in the USA
Volume 3 , Issue 11
癌症的单克隆抗体免疫治疗
Monoclonal antibodies for cancer immunotherapy
Volume 3 , Issue 10
行非紧急经皮冠状动脉介入治疗的患者使用SCH530348的安全性和耐受性：一项随机、双盲、安慰剂对照II期研究
Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study
Volume 3 , Issue 9
普拉格雷与氯吡格雷用于拟行PCI的ST段抬高型心肌梗死患者的比较（TRITON-TIMI 38）：一项双盲、随机对照研究
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial
Volume 3 , Issue 8
人类异体颜面移植：一项2年随访研究
Human facial allotransplantation: a 2-year follow-up study
Volume 3 , Issue 7
应用抑酸剂、H2受体拮抗剂和质子泵抑制剂升序或降序治疗新发消化不良的效果与成本效益分析（DIAMOND研究）：一项基于初级保健的随机对照试经验
Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H₂-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial
Volume 3 , Issue 6
GALA 临床试验：未能定论的回答
The GALA trial: answers it gives, answers it does not
Volume 3 , Issue 5
急性缺血性卒中发病3～4.5 h行阿替普酶溶栓治疗（SITS-ISTR）：一项观察性研究
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
Volume 3 , Issue 4
血管紧张素受体阻断剂替米沙坦对不耐受血管紧张素转换酶抑制剂的高危患者心血管事件的作用：一项随机对照试验
Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
Volume 3 , Issue 3
一项关于瑞舒伐他汀在慢性心力衰竭患者中效应的随机、双盲、安慰剂对照试验：GISSI-HF试验
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
Volume 3 , Issue 2
组织工程气管临床移植
Clinical transplantation of a tissue-engineered airway
Volume 3 , Issue 1
在稳定型冠心病伴左室收缩功能障碍的患者中应用伊伐布雷定（BEAUTIFUL）：一项随机、双盲、安慰剂对照试验
Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
 2008
Volume 2 , Issue 12
心率作为冠心病与左室收缩障碍患者的预后危险因素（BEAUTIFUL）：一项随机、对照试验的一个亚组分析
Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial
Volume 2 , Issue 11
Dimebon对轻中度阿尔茨海默病患者认知、日常活动、行为和总体功能的影响：一项随机、双盲、安慰剂对照研究
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
Volume 2 , Issue 10
胰岛素强化治疗对新诊断2型糖尿病患者B细胞功能和血糖控制的影响：一项多中心、随机、平行组研究
Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
Volume 2 , Issue 9
肝硬化
Liver cirrhosis
Volume 2 , Issue 8
儿童肾血管性高血压
Renovascular hypertension in children
Volume 2 , Issue 7
前列腺癌
Prostate cancer
Volume 2 , Issue 6
静脉注射甲氧基聚乙二醇促红细胞生成素-β对慢性肾病透析患者血红蛋白浓度的稳定作用：一项随机非劣效性试验（MAXIMA）
Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA)
Volume 2 , Issue 5
对雌激素受体缺乏乳腺癌进行辅助化疗：随机试验的患者水平荟萃分析
Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials
Volume 2 , Issue 4
他汀类药物在临床实践中的安全性
The safety of statins in clinical practice
Volume 2 , Issue 3
登革热
Dengue
Volume 2 , Issue 2
主要心脏事件高危或低危患者中药物洗脱支架的成本-效益：BASKET试验的18个月分析
Cost-effectiveness of drug-eluting stents in patients at high or low risk of major cardiac events in the Basel Stent KostenEffektivitäts Trial (BASKET): an 18-month analysis
Volume 2 , Issue 1
婴儿急性淋巴细胞白血病治疗方案(Interfant-99 ) ：一项多中心随机临床试验及观察研究
A treatment protocol for infantsyounger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomized trial
 2007
Volume 1 , Issue 6
预防性二价L1病毒样颗粒佐剂疫苗在对抗年轻女性感染16与18型人乳头瘤病毒中的效应：一项III期、双盲、随机对照试验的期中分析
Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blin
Volume 1 , Issue 5
他莫昔芬治疗2-3 年后改用依西美坦或持续使用他莫昔芬治疗的存活性与安全性研究（依西美坦协作组研究）：一项随机、对照试验
Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial
Volume 1 , Issue 4
阿司匹林在结肠直肠癌远期发病风险中的效用：随机试验和观察性研究的一致性证据
Effect of aspirin on long-term risk of colorectal cancer : consistent evidence from randomised and observational studies
Volume 1 , Issue 3
SITS-MOST 中应用阿替普酶对急性缺血性卒中进行溶栓治疗：一项观察研究
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study ( SITS-MOST ) : an observational study
Volume 1 , Issue 2
HER2 阳性乳腺癌辅助化疗后应用曲妥单抗治疗的2年随访研究：一项随机对照试验
2 - year follow - up of trastuzumab after adjuvant chemotherapy in HER2 -positive breast Cancer : a randomized controlled trial
Volume 1 , Issue 1
6-硫鸟嘌呤与 6-巯基嘌呤对儿童淋巴细胞白血病患者毒性及疗效的对比、随机试验
Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia : a randomised trial
 2006
Volume 3 , Issue 6
连续性静脉血液透析滤过与间歇性血液透析对多器官功能障碍：综合征伴急性肾衰患者的疗效比较：一项多中心随机试验
Continuous venovenous heamodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial
Volume 3 , Issue 5
中性粒细胞在脓毒症引起多器官功能衰竭中的作用
Neutrophils in development of multiple organ failure in sepsis
Volume 3 , Issue 4
ACTIVE W：氯吡格雷加阿司匹林与单用口服抗凝药物治疗房颤的随机、对照试验
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events ( ACTIVE W ) : a randomized
Volume 3 , Issue 3
多奈哌齐治疗重度阿尔茨海默病的双盲、平行组、安慰剂对照研究
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
Volume 3 , Issue 2
自体骨髓干细胞移植治疗 ST 段抬高型心肌梗死患者的双盲、随机对照试验
Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction:double-blind, randomised controlled trial
Volume 3 , Issue 1
氯吡格雷联合阿司匹林对45852例急性心肌梗死患者的疗效评价：一项随机、安慰剂对照试验
Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction : randomised placebo-controlled trial

关注糖尿病，聚焦GLP-1！案例征集大赛
时间：2011-3~~2011-11
由中国医师协会主办、礼来国际贸易（上海）有限公司协办、爱思唯尔国际出版集团承办的“精彩案例我分享——关注糖尿病•聚焦GLP-1”案例征集活动将于2011年3月~ 11月在全国范围隆重展开。

关注青光眼患者， 让世界更明亮！
时间：2011-4~~2011-12
《中华眼科杂志》发起，辉瑞制药资助，旨在交流青光眼治疗理念，分享国内抗青光眼药物固定联合治疗经验的病例交流活动.

聚焦哮喘和COPD联合制剂治疗
时间：2010-12~~2011-12
哮喘和慢性阻塞性肺疾病（COPD）是常见、多发的气道炎症性疾病，这类疾病严重影响患者的生活质量。我们特别组织了该类案例征集活动，奖品丰厚，快来参与！

中国选择 达标看我
时间：2011-9~~2012-9
本次活动对典型病例以分享的形式总结临床经验，通过跨专科、多层次的学术交流，对降压治疗方案、疗效进行解析与点评。

 

慢性心衰诊治：规范中求突破
黄峻
2012-2-1
南京医科大学第一附属医院
房颤治疗：手段渐趋丰富 新型治疗药物不断涌现 非药物治疗备受关注
马长生
2012-2-1
首都医科大学附属北京安贞医院
注重老年人群特征 优化管理

刘梅林
2012-2-1
北京大学第一医院老年内科