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中国作者重要发表
标题：胰腺癌细胞系中对吉西他滨的内在化疗耐药与组成性和层黏连蛋白诱导的FAK磷酸化相关
Molecular Cancer, 2009, Volume: 8
作者：Huanwen W, Zhiyong L, Xiaohua S, Xinyu R, Kai W, Tonghua L
内容预览：Background: One of the major reasons for poor prognosis of pancreatic cancer is its high resistance to currently available chemotherapeutic agents. In recent years, focal adhesion kinase (FAK), a central molecule in extracellular matrix (ECM)/integrin-mediated signaling, has been thought to be a key determinant of chemoresistance in cancer cells. In this study, we aimed to determine the roles of FAK phosphorylation in the intrinsic chemoresistance of pancreatic cancer cell lines.Results: Our results showed that, the level of constitutive phosphorylation of FAK at Tyr397 correlated with the extent of intrinsic resistance to Gemcitabine (Gem) in four pancreatic cancer cell lines. Moreover, in Panc-1 cells, which had high expression of pFAK, specific inhibition of constitutive FAK...
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