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中国作者重要发表
标题：脂联素通过AdipoR1-AMPK-iNOS通路抑制脂多糖诱导的动脉外膜成纤维细胞迁移及其向成肌纤维细胞的转变
Molecular Endocrinology, 2010, Volume: 24, Issue: 1
作者：Cai X-J, Chen L, Li L, Feng M, Li X, Zhang K, Rong Y-Y, Hu X-B, Zhang M-X, Zhang Y, Zhang M
内容预览：Adiponectin is an important antiatherogenic adipocytokine that inhibits inflammation, insulin resistance, and oxide stress. Inflammation in the vascular adventitia is a crucial factor in the pathogenesis of atherosclerosis. Adventitial fibroblasts (AFs) can proliferate, divide into myofibroblasts, and migrate to the intima to become a new component of atherosclerotic plaque under inflammation and atherosclerosis. We investigated whether adiponectin might prevent AFs from proliferating, migrating, and transforming into myofibroblasts. Cultured AFs were stimulated with lipopolysaccharide (LPS) in the presence or absence of adiponectin. Methyl thiazolyl tetrazolium assay and migration and scratch-wound assays demonstrated that adiponectin reduced the AF proliferation and migration induced by...
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