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爱思唯尔期刊精选全文
标题：质子泵抑制剂的长期安全性
American Journal of Medicine, 2009, Volume: 122, Issue: 10
作者：Tauseef Ali MD, David Neil Roberts MD and William M. Tierney MD
内容预览：Abstract
Proton pump inhibitors (PPIs) are among the most widely prescribed medications worldwide. Their use has resulted in dramatic improvements in treatment of peptic ulcer disease and gastroesophageal reflux disease. Despite an acceptable safety profile, mounting data demonstrate concerns about the long-term use of PPIs. To provide a comprehensive review regarding the concerns of long-term PPI use, a literature search was performed to identify pertinent original and review articles. Despite study shortcomings, the collective body of information overwhelmingly suggests an increased risk of infectious complications and nutritional deficiencies. Data regarding any increased risk in gastric or colon malignancy are less convincing. PPIs have revolutionized the management and complications...
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