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爱思唯尔期刊精选全文
标题：热休克蛋白70基因变异体的相互作用与新疆和田地区维吾尔族人的长寿现象
Translational Research, 2009, Volume: 154, Issue: 5
作者：Jinxin Li, Wenquan Niu, Yue Qid, Wufuer Mayila, Pengcheng Zhu, Muhuyati, Zuheng Cheng, and Changchun Qiu
内容预览：Mounting evidence suggests that all organisms at the cellular level respond to stress by synthesizing heat shock proteins at the expense of other proteins, and the ability of human cells to respond to heat stress decreases with aging. We thus investigate the association of 3 variants (A1267G in HSPA1B, G190C in HSPA1A, and T2437C in HSPA1L) in the heat shock protein 70 (Hsp70) family with natural longevity in a Xinjiang Hetian Uygur population. A case-control study was conducted in 191 healthy individuals greater than 90 years of age, and 53 naturally died persons 65–70 years of age. Promoter activity was evaluated by luciferase reporter assays. The data were analyzed using an EH/EH+ program for haplotype prediction and MDR software for gene–gene interaction. All studied variants...
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