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Volume 4, Issue 2 


中文标题: 剂量密集紫杉醇联合卡铂治疗晚期卵巢癌：一项开放标记的III期随机对照试验  

英文标题: Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial  

作者: Noriyuki Katsumata, Makoto Yasuda, Fumiaki Takahas...

全文: 背 景　 紫杉醇和卡铂每3周1次是晚期卵巢癌的标准治疗方法，但临床疗效并不理想。一些研究试图纳入其他药物来改善患者存活但结果令人失望。本文作者旨在比较常规的紫杉醇和卡铂方案与每周1次的剂量密集方案对晚期卵巢癌患者的效应。   方 法 　研究为一项开放标记的Ⅲ期随机对照试验，入组患者为日本85所医疗中心的Ⅱ～Ⅳ期上皮性卵巢癌、输卵管癌或原­发性腹膜癌患者。采用计算机...
 
往期免费全文 <span class="ModTitle_Intro">[<a href="http://portal.elseviermed.cn/tabid/123/Default.aspx">栏目介绍</a>]</span>  往期免费全文 [栏目介绍]
 2010
 2009
Volume 3 , Issue 12
美国1例严重毁容患者的近全颜面移植
Near-total human face transplantation for a severely disfigured patient in the USA
Volume 3 , Issue 11
癌症的单克隆抗体免疫治疗
Monoclonal antibodies for cancer immunotherapy
Volume 3 , Issue 10
行非紧急经皮冠状动脉介入治疗的患者使用SCH530348的安全性和耐受性：一项随机、双盲、安慰剂对照II期研究
Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study
Volume 3 , Issue 9
普拉格雷与氯吡格雷用于拟行PCI的ST段抬高型心肌梗死患者的比较（TRITON-TIMI 38）：一项双盲、随机对照研究
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial
Volume 3 , Issue 8
人类异体颜面移植：一项2年随访研究
Human facial allotransplantation: a 2-year follow-up study
Volume 3 , Issue 7
应用抑酸剂、H2受体拮抗剂和质子泵抑制剂升序或降序治疗新发消化不良的效果与成本效益分析（DIAMOND研究）：一项基于初级保健的随机对照试经验
Effect and cost-effectiveness of step-up versus step-down treatment with antacids, H₂-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial
Volume 3 , Issue 6
GALA 临床试验：未能定论的回答
The GALA trial: answers it gives, answers it does not
Volume 3 , Issue 5
急性缺血性卒中发病3～4.5 h行阿替普酶溶栓治疗（SITS-ISTR）：一项观察性研究
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study
Volume 3 , Issue 4
血管紧张素受体阻断剂替米沙坦对不耐受血管紧张素转换酶抑制剂的高危患者心血管事件的作用：一项随机对照试验
Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
Volume 3 , Issue 3
一项关于瑞舒伐他汀在慢性心力衰竭患者中效应的随机、双盲、安慰剂对照试验：GISSI-HF试验
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
Volume 3 , Issue 2
组织工程气管临床移植
Clinical transplantation of a tissue-engineered airway
Volume 3 , Issue 1
在稳定型冠心病伴左室收缩功能障碍的患者中应用伊伐布雷定（BEAUTIFUL）：一项随机、双盲、安慰剂对照试验
Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
 2008
Volume 2 , Issue 12
心率作为冠心病与左室收缩障碍患者的预后危险因素（BEAUTIFUL）：一项随机、对照试验的一个亚组分析
Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial
Volume 2 , Issue 11
Dimebon对轻中度阿尔茨海默病患者认知、日常活动、行为和总体功能的影响：一项随机、双盲、安慰剂对照研究
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
Volume 2 , Issue 10
胰岛素强化治疗对新诊断2型糖尿病患者B细胞功能和血糖控制的影响：一项多中心、随机、平行组研究
Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
Volume 2 , Issue 9
肝硬化
Liver cirrhosis
Volume 2 , Issue 8
儿童肾血管性高血压
Renovascular hypertension in children
Volume 2 , Issue 7
前列腺癌
Prostate cancer
Volume 2 , Issue 6
静脉注射甲氧基聚乙二醇促红细胞生成素-β对慢性肾病透析患者血红蛋白浓度的稳定作用：一项随机非劣效性试验（MAXIMA）
Intravenous methoxy polyethylene glycol-epoetin beta for haemoglobin control in patients with chronic kidney disease who are on dialysis: a randomised non-inferiority trial (MAXIMA)
Volume 2 , Issue 5
对雌激素受体缺乏乳腺癌进行辅助化疗：随机试验的患者水平荟萃分析
Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials
Volume 2 , Issue 4
他汀类药物在临床实践中的安全性
The safety of statins in clinical practice
Volume 2 , Issue 3
登革热
Dengue
Volume 2 , Issue 2
主要心脏事件高危或低危患者中药物洗脱支架的成本-效益：BASKET试验的18个月分析
Cost-effectiveness of drug-eluting stents in patients at high or low risk of major cardiac events in the Basel Stent KostenEffektivitäts Trial (BASKET): an 18-month analysis
Volume 2 , Issue 1
婴儿急性淋巴细胞白血病治疗方案(Interfant-99 ) ：一项多中心随机临床试验及观察研究
A treatment protocol for infantsyounger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomized trial
 2007
Volume 1 , Issue 6
预防性二价L1病毒样颗粒佐剂疫苗在对抗年轻女性感染16与18型人乳头瘤病毒中的效应：一项III期、双盲、随机对照试验的期中分析
Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blin
Volume 1 , Issue 5
他莫昔芬治疗2-3 年后改用依西美坦或持续使用他莫昔芬治疗的存活性与安全性研究（依西美坦协作组研究）：一项随机、对照试验
Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial
Volume 1 , Issue 4
阿司匹林在结肠直肠癌远期发病风险中的效用：随机试验和观察性研究的一致性证据
Effect of aspirin on long-term risk of colorectal cancer : consistent evidence from randomised and observational studies
Volume 1 , Issue 3
SITS-MOST 中应用阿替普酶对急性缺血性卒中进行溶栓治疗：一项观察研究
Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study ( SITS-MOST ) : an observational study
Volume 1 , Issue 2
HER2 阳性乳腺癌辅助化疗后应用曲妥单抗治疗的2年随访研究：一项随机对照试验
2 - year follow - up of trastuzumab after adjuvant chemotherapy in HER2 -positive breast Cancer : a randomized controlled trial
Volume 1 , Issue 1
6-硫鸟嘌呤与 6-巯基嘌呤对儿童淋巴细胞白血病患者毒性及疗效的对比、随机试验
Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia : a randomised trial
 2006
Volume 3 , Issue 6
连续性静脉血液透析滤过与间歇性血液透析对多器官功能障碍：综合征伴急性肾衰患者的疗效比较：一项多中心随机试验
Continuous venovenous heamodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial
Volume 3 , Issue 5
中性粒细胞在脓毒症引起多器官功能衰竭中的作用
Neutrophils in development of multiple organ failure in sepsis
Volume 3 , Issue 4
ACTIVE W：氯吡格雷加阿司匹林与单用口服抗凝药物治疗房颤的随机、对照试验
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events ( ACTIVE W ) : a randomized
Volume 3 , Issue 3
多奈哌齐治疗重度阿尔茨海默病的双盲、平行组、安慰剂对照研究
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study
Volume 3 , Issue 2
自体骨髓干细胞移植治疗 ST 段抬高型心肌梗死患者的双盲、随机对照试验
Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction:double-blind, randomised controlled trial
Volume 3 , Issue 1
氯吡格雷联合阿司匹林对45852例急性心肌梗死患者的疗效评价：一项随机、安慰剂对照试验
Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction : randomised placebo-controlled trial

病例分析 <span class="ModTitle_Intro_Right" id="EPMI_Home_MedicalCases_Intro_div" onclick="javascript:window.location='http://portal.elseviermed.cn/tabid/127/Default.aspx'" onmouseover="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.cursor='pointer';document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='underline';" onmouseout="javascript:document.getElementById('EPMI_Home_MedicalCases_Intro_div').style.textDecoration='none';">[栏目介绍]</span>  病例分析 [栏目介绍]
室性心动过速多次发作
摘自：《西氏内科学》，第23版
 
患者男性，29岁，因室性心动过速多次发作入院，待行心脏电复律。患者平素体健，自诉于大约5个月前，出现气短、心悸、胸痛的急性发作，并有胸闷感。患者因心电图提示单形性室性心动过速到急诊科就诊。采用胺碘酮行药物复律后无效，但心电图恢复窦性心律。
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