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蔓荆子(BNO 1095)治疗中国妇女中至重度经前期综合征症状的疗效评估

Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women
Ma L, Lin S, Chen R   |    2010/7/30 15:42:55   | 
Aust N Z J Obstet Gynaecol  |   2010   |          View at Publisher
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Objectives:
To assess therapeutic effect of an extract of Vitex agnus castus (VAC, BNO 1095) in premenstrual syndrome (PMS) in Chinese women.

Design:
It was a prospective, randomised, double-blind, placebo-controlled study carried out in China. Eligible patients were treated with VAC extract or placebo for three cycles. Symptoms were documented with PMS diary (PMSD), a daily rating scale with 17 items. Main efficacy variable was the reduction percentage of 17 symptom score documented in PMSD during the luteal phase of the third treatment cycle.

Results:
A total of 67 patients were enrolled and randomly assigned to VAC group or placebo group. Of these, 64 patients completed the study (31 vs. 33). All the 17 symptoms showed a significantly greater improvement with VAC than placebo (P<0.05) except lower abdominal cramping (P>0.05).

Conclusion:
Vitex agnus castus is more effective than placebo in the treatment of moderate-to-severe PMS in Chinese women, especially in symptoms of negative effect and insomnia.
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刘梅林
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北京大学第一医院老年内科

 
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