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瘘管切开术的预后：一项前瞻性多中心区域性研究的结果

Outcomes After Fistulotomy: Results of a Prospective, Multicenter Regional Study
Hyman N, O'Brien S, Osler T   |    2010/8/9 15:04:29   | 
Dis Colon Rectum  |   2010   |          View at Publisher
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Purpose:
This study aimed to determine the outcomes and healing rate after fistula surgery across a broad spectrum of colorectal practices.

Methods:
A prospective, multicenter outcomes registry was created by the New England Regional Chapter of The American Society of Colon and Rectal Surgeons. All consecutive patients undergoing surgical treatment of an anal fistula by a participating surgeon from October 1, 2007 to September 30, 2008, were entered. Demographics, fistula characteristics including Parks' classification, smoking history, previous vaginal deliveries, diagnosis of Crohn's disease, Fecal Incontinence Severity Index, and operations performed were noted. A follow-up datasheet recorded postoperative complications, healing at one and three months, and postoperative continence scores. Factors associated with healing and treatment success were compared by use of Fisher's exact test.

Results:
Twenty-five surgeons at 13 hospitals entered 245 patients (162 male, 83 female) in the registry. Seventy-five patients had recurrent fistulas, 51 had multiple tracts, 62 were smokers, and 24 had Crohn's disease. The overall healing rate was 19.5% at one month and 63.2% at three months. Female gender (P=0.04) and recurrent fistula (P=0.03) were associated with nonhealing, and 28.4% of patients required additional surgery. The best healing rate was associated with fistulotomy (87%), whereas a plug had the worst healing rate (32%, P=0.001).

Conclusions:
Surgical treatment of an anal fistula is associated with a substantial risk of nonhealing at three months. Fistulotomy had a high success rate, whereas the bioprosthetic plug had the lowest success rate.

Multicenter studies comparing treatment options for similar fistulas are needed.
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