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晚期卵巢癌大肿瘤完全切除的预后因素及其对生存率的影响：AGO-OVA前瞻性、随机对照的III期临床研究的探索性分析

Prognostic factors for complete debulking in advanced ovarian cancer and its impact on survival. An exploratory analysis of a prospectively randomized phase III study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVA
Wimberger P, for the AGO-OVAR   |    2009/5/27 10:50:52   | 
Gynecol Oncol  |   2007   |          View at Publisher
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下一篇： 头颈部癌症患者经高剂量放疗或联合西妥昔单抗治疗后的生活质量
Abstract
Background:
No residual tumor as result of primary surgery in advanced ovarian cancer is known as one of the most important prognostic factors.

Purpose:
To evaluate the impact of different prognostic factors for surgical outcome and to evaluate the impact of surgical outcome on survival.

Methods:
Surgical data as well as survival data were documented throughout the multi-center prospective randomized phase III trial (OVAR-3) of the AGO-OVAR and were used for this exploratory analysis. In this study 798 patients with FIGO IIB-IV were first operated then randomized and homogenously treated with cisplatin/paclitaxel or carboplatin/paclitaxel. Only patients with complete surgical data (n=761) entered this analysis.

Results:
Multivariable logistic regression analysis showed a significant decrease of probability for complete debulking without any macroscopic residual tumor for higher pre-operative tumor load (OR 0.32; 95% CI 0.17–0.61), higher FIGO stage (OR 0.22; 95% CI 0.13–0.39), worse performance status (OR 0.57; 95% CI 0.38–0.86), advanced age (OR 0.78; 95% CI 0.65–0.94) and presence of peritoneal carcinomatosis (OR 0.17; 95% CI 0.10–0.28). Surgery in centers with surgeons who performed comprehensive surgical debulking including retroperitoneal lymphadenectomy and peritoneal stripping was associated with higher rates of complete debulking compared to surgery in other centers (32.8% vs. 22.9%, p=0.007). This resulted in a markedly improved overall survival (p=0.045). This effect was held true after adjustment for prognostic factors (HR 0.77, 95% CI 0.63–0.94, p=0.012).

Conclusion:
Post-operative residual tumor is one of the most important independent prognostic factor for survival. Our results suggest an advantage for aggressive primary surgery and complete debulking. This surgical goal was achieved more often in experienced centers.
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