立即登录 | 免费注册
全部学科 | 内科学 | 心血管病学 | 内分泌学与糖尿病 | 神经病学 | 消化病学 | 呼吸病学 | 肿瘤学 | 妇产科学 | 骨科学
疾病中心： 高血压 | 冠心病 | 心力衰竭 | 心律失常 | 脂肪性肝病 | 糖尿病 | 卒中 | 慢性阻塞性肺病 | 子宫内膜异位症 | 乳腺癌 | 肺癌 | 结直肠癌 | 器官移植
Loading
当前位置：期刊中心 > 中国作者重要发表 > 文摘导读

中国非糖尿病患者的代谢综合征和血压盐敏性：一项膳食干预研究

Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study
Chen J., Gu D., Huang J., Rao D.C., Jaquish C.E., Hixson J.E., Chen C.-S., Chen J., Lu F., Hu D., Rice T., Kelly T.N., Hamm L.L., Whelton P.K., He J.   |   2009/5/29 18:39:20 
The Lancet, 2009   |   Volume 373, Issue 9666  |   打印| 推荐给好友
上一篇: 谷氨酸通过N -甲基- D -天门冬氨酸受体介导的高氧性新生大鼠肺损伤
下一篇: 三聚氰胺污染的配方奶粉与幼儿尿路结石
Background: Since insulin resistance is thought to be the underlying mechanism for metabolic syndrome, affected individuals might be sensitive to a dietary sodium intervention. We aimed to examine the association between metabolic syndrome and salt sensitivity of blood pressure. Methods: 1906 Chinese participants without diabetes, aged 16 years or more, were selected to receive a low-sodium diet (51·3 mmol per day) for 7 days followed by a high-sodium diet (307·8 mmol per day) for an additional 7 days. Participants were excluded from the analysis if metabolic risk factor information was missing or if they did not complete their dietary interventions. Blood pressure was measured at baseline and on days 2, 5, 6, and 7 of each intervention. Metabolic syndrome was defined as the presence of three or more of: abdominal obesity, raised blood pressure, high triglyceride concentration, low HDL cholesterol, or high glucose. High salt sensitivity was defined as a decrease in mean arterial blood pressure of more than 5 mm Hg during low-sodium or an increase of more than 5 mm Hg during high-sodium intervention. This study is registered with ClinicalTrials.gov, number NCT00721721. Findings: Of the 1881 participants with information regarding metabolic syndrome, 283 had metabolic syndrome. 1853 participants completed the low-sodium diet and 1845 completed the high-sodium diet. Multivariable-adjusted mean changes in blood pressure were significantly greater in participants with metabolic syndrome than in those without on both low-sodium and high-sodium diets (p<0·0001 for all comparisons). Additionally, risk of salt sensitivity rose with increasing numbers of risk factors for metabolic syndrome. Compared with those with no risk factors, participants with four or five had a 3·54-fold increased odds (95% CI 2·05-6·11) of high salt-sensitivity during the low-sodium and a 3·13-fold increased odds (1·80-5·43) of high salt-sensitivity during the high-sodium intervention. Interpretation: These results suggest that metabolic syndrome enhances blood pressure response to sodium intake. Reduction in sodium intake could be an especially important component in reducing blood pressure in patients with multiple risk factors for metabolic syndrome. Funding: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. © 2009 Elsevier Ltd. All rights reserved.
Correspondence Address: Chen, J.; Department of Medicine and Tulane Hypertension, Renal Center of Excellence, School of Medicine, New Orleans, LA, United States; email: jchen@tulane.edu 
关键词:
 
唯医 说： 2009-7-4
支持
【回复】
Grace Hao 说： 2009-6-24
很不错的研究，值得一读
【回复】

请登录后发表评论，点击此处登录。
相关文章

关注糖尿病，聚焦GLP-1！案例征集大赛
时间：2011-3~~2011-11
由中国医师协会主办、礼来国际贸易（上海）有限公司协办、爱思唯尔国际出版集团承办的“精彩案例我分享——关注糖尿病•聚焦GLP-1”案例征集活动将于2011年3月~ 11月在全国范围隆重展开。

关注青光眼患者， 让世界更明亮！
时间：2011-4~~2011-12
《中华眼科杂志》发起，辉瑞制药资助，旨在交流青光眼治疗理念，分享国内抗青光眼药物固定联合治疗经验的病例交流活动.

聚焦哮喘和COPD联合制剂治疗
时间：2010-12~~2011-12
哮喘和慢性阻塞性肺疾病（COPD）是常见、多发的气道炎症性疾病，这类疾病严重影响患者的生活质量。我们特别组织了该类案例征集活动，奖品丰厚，快来参与！

中国选择 达标看我
时间：2011-9~~2012-9
本次活动对典型病例以分享的形式总结临床经验，通过跨专科、多层次的学术交流，对降压治疗方案、疗效进行解析与点评。

 

慢性心衰诊治：规范中求突破
黄峻
2012-2-1
南京医科大学第一附属医院
房颤治疗：手段渐趋丰富 新型治疗药物不断涌现 非药物治疗备受关注
马长生
2012-2-1
首都医科大学附属北京安贞医院
注重老年人群特征 优化管理

刘梅林
2012-2-1
北京大学第一医院老年内科