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Semaphorin-3A指引发育过程中皮层神经元的放射状迁移
Semaphorin-3A guides radial migration of cortical neurons during development
Chen G., Sima J., Jin M., Wang K.-Y., Xue X.-J., Zheng W., Ding Y.-Q., Yuan X.-B.  2009/5/29 18:40:20 
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Nature Neuroscience, 2008, Volume 11, Issue 1 
 
Postmitotic neurons in the developing cortex migrate along radial glial fibers to their proper location in the cortical plate and form the layered structure. Here we report that the radial migration of rat layer II/III cortical neurons requires guidance by the extracellular diffusible factor Semaphorin-3A (Sema3A). This factor is expressed in a descending gradient across the cortical layers, whereas its receptor neuropilin-1 (NP1) is highly expressed in migrating neurons. Downregulation or conditional knockout of NP1 in newborn cortical neurons impedes their radial migration by disrupting their radial orientation during migration without altering their cell fate. Studies in cultured cortical slices further show that the endogenous gradient of Sema3A is required for the proper migration of newborn neurons. In addition, transwell chemotaxis assays show that isolated newborn neurons are attracted by Sema3A. Thus, Sema3A may function as a chemoattractive guidance signal for the radial migration of newborn cortical neurons toward upper layers. © 2008 Nature Publishing Group.
Correspondence Address: Yuan, X.-B.; Institute of Neuroscience, Key State Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Shanghai 200031, China; email: yuanxb@ion.ac.cn 
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呼吸急促伴精神状态改变——《西氏内科学》病例

摘自：《西氏内科学》，第23版

 

患者男性，36岁，幼年有吸入性肺损伤史，因呼吸急促和精神状态改变来我院就诊。患者睡眠和运动时，吸氧流量基值为2 L/min，每天均进行肺功能康复训练。患者居住在美国中西部，入院5天前曾离家乘船来这里看望其兄弟。入院前一天，患者呼吸急促加剧，自觉发热并注意到其慢性咳嗽稍加重，但痰液无变化。当天晚上，家人注意到患者更加急躁并有点偏执。由于症状加重，患者于次日送我院就诊。

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