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中枢神经系统内的钠尿肽及其受体
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Natriuretic peptides and their receptors in the central nervous system
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Cao L.-H., Yang X.-L.
2009/5/29 18:40:20
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Progress in Neurobiology,
2008,
Volume 84,
Issue 3
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Natriuretic peptides (NPs), including atrial, brain and C-type NPs, are a family of structurally related but genetically distinct peptides. These peptides, along with their receptors (NPRs), are long known to be involved in the regulation of various physiological functions, such as diuresis, natriuresis, and blood flow. Recently, abundant evidence shows that NPs and NPRs are widely distributed in the central nervous system (CNS), suggesting possible roles of NPs in modulating physiological functions of the CNS. This review starts with a brief summary of relevant background information, such as molecular structures of NPs and NPRs and general intracellular mechanisms after activation of NPRs. We then provide a detailed description of the expression profiles of NPs and NPRs in the CNS and an in-depth discussion of how NPs are involved in neural development, neurotransmitter release, synaptic transmission and neuroprotection through activation of NPRs. © 2007 Elsevier Ltd. All rights reserved.
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Correspondence Address:
Yang, X.-L.; Institute of Neurobiology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, 138 Yixueyuan Road, Shanghai, 200032, China; email:xlyang@fudan.edu.cn
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疾病资源中心
曹晶珠 邹大进
解放军第二军医大学附属长海医院内分泌科
患者为中年女性，35岁，因“多饮、多尿、全身乏力、闭经1年，体重增加、肝区不适半年”于2008年8月入院。患者2007年感冒后出现多饮、多尿，每日饮水约10,000 ml，未予重视及诊治。2007年出现闭经，在外院妇产科就诊，先后予2次黄体酮肌肉注射，仍未来月经。半年前体重增加25 kg，肝区不适，肝功能示转氨酶升高。患者无便秘腹胀、无皮肤感染、无双下肢水肿，活动后稍感胸闷、气喘，夜尿增多，平均每小时1次。最大体重88.7 kg。既往史无特殊。月经史：初潮14岁，4/28～30，2008年6月。
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